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O-1821 Catalog No.:M22754-C 4 nM for PARP1 in

SKU: 37924343457

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Description

4 nM for PARP1 in a cell-free assay

Casticin (0-40 μM) dose-dependently inhibits the proliferation of LX2 cells

GNE-049 is further evaluated in a rat single dose (30-250 mg/kg QD) toxicokinetic study

Smiles: COC(=O)N[C@H]1CCC[C@@H]1[C@@](CN1CCC1)(C1CCN(CC2(CN(C2)C2=CC=C(C=C2)S(=O)(=O)N2C[C@@H]3C[C@H]2CN3C(=O)C=C)OC)CC1)C1=CC(F)=CC=C1

Formula: C19H18O4

O-1821 Catalog No.:M22754-C 4 nM for PARP1 inO 1821 is an cannabidiol analog with similar structure to O 1918, a selective antagonist of abnormal cannabidiol. Abnormal cannabidiol, a synthetic regioisomer of cannabidiol, fails to elicit either central cannabinoid (CB1) or peripheral cannabinoid (CB2) receptors and is lack of psychotropic activity. It can induce endothelium dependent vasodilation through a CB1 CB2 nitric oxide independent mechanism. In vitro: O 1821 is a cannabidiol analog with

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